Ventura, who has given up just four earned runs in his last 32 innings, was dominant in his seven innings of work, striking out 11 while giving up just one run.
Kansas City added two more in the 2nd inning on a Cheslor Cuthbert two-RBI single to make it 3-0.
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After Ventura struck out the side in the 3rd, the Lorenzo show took over, beginning with a mammoth solo home run from Cain to put the Royals up 4-0.
Both Cain and Hosmer’s runs were charged to Wolf, who gave up eight earned runs in just 3 2/3 innings pitched.
The Royals weren’t finished just yet, however.
After a Salvador Perez walk, Cuthbert hit his first career home run to pad the Royals lead even further at 11-0.
The 12-1 win put the Royals back at 30-games above .500 at 81-51, while the loss moved the Tigers back to 10-games below .500 at 61-71.